Background:

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602).

Applications:

ELISA, WB, IHC

Name of antibody:

MCRS1

Immunogen:

Fusion protein of human MCRS1

Full name:

microspherule protein 1

Synonyms:

P78; MCRS2; MSP58; INO80Q; ICP22BP

SwissProt:

Q96EZ8

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

100-300

WB Predicted band size:

52 kDa

WB Positive control:

293T cell lysate

WB Recommended dilution:

500-2000