Background:

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Applications:

ELISA, IHC

Name of antibody:

TNF

Immunogen:

Synthetic peptide of human TNF

Full name:

tumor necrosis factor

Synonyms:

DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha

SwissProt:

P01375

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancerHuman liver cancer

IHC Recommend dilution:

20-100